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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
O94925
USC-OGP 2-DE database
:
O94925
O94925
General information about the entry
View entry in simple text format
Entry name
GLSK_HUMAN
Primary accession number
O94925
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Glutaminase kidney isoform, mitochondrial; Short=GLS; EC=3.5.1.2; AltName: Full=K-glutaminase; AltName: Full=L-glutamine amidohydrolase; Flags: Precursor;.
Gene name
Name=GLS
Synonyms=GLS1, KIAA0838
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1148
:
pI=6.34; Mw=55360
Cross-references
UniProtKB/Swiss-Prot
O94925; GLSK_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
GLSK_HUMAN
Primary accession number
O94925
Secondary accession number(s)
Q9UL05 Q9UL06 Q9UL07 Q9UN40
Sequence was last modified on
May 1, 1999 (version 1)
Annotations were last modified on
March 15, 2017 (version 172)
Name and origin of the protein
Description
RecName: Full=Glutaminase kidney isoform, mitochondrial; Short=GLS; EC=3.5.1.2; AltName: Full=K-glutaminase; AltName: Full=L-glutamine amidohydrolase; Flags: Precursor;
Gene name
Name=GLS
Synonyms=GLS1, KIAA0838
Encoded on
Name=GLS; Synonyms=GLS1, KIAA0838
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
ANK repeat
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Hydrolase
;
Mitochondrion
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Repeat
;
Transit peptide
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
AF158555; AAD47056.1
; -; mRNA
EMBL
AF097492; AAF00088.1
; -; mRNA
EMBL
AF097493; AAF00089.1
; -; mRNA
EMBL
AF097495; AAF00090.1
; -; mRNA
EMBL
AB020645; BAA74861.2
; ALT_INIT; mRNA
EMBL
AF223943; AAF33825.1
; -; mRNA
EMBL
AF327434; AAG47842.1
; -; mRNA
EMBL
BC038507; AAH38507.2
; -; mRNA
EMBL
AF279697; AAG17700.1
; -; mRNA
CCDS
CCDS2308.1; -. [O94925-1]
; .
CCDS
CCDS58744.1; -. [O94925-3]
; .
RefSeq
NP_001243239.1; NM_001256310.1. [O94925-3]
; .
RefSeq
NP_055720.3; NM_014905.4. [O94925-1]
; .
UniGene
Hs.116448; -
; .
UniGene
Hs.737608; -
; .
PDB
3CZD; X-ray
; 2.40 A; A=221-533
PDB
3UNW; X-ray
; 2.56 A; A/B/C/D=71-597
PDB
3UO9; X-ray
; 2.30 A; A/B/C/D=71-597
PDB
3VOY; X-ray
; 2.20 A; A=221-533
PDB
3VOZ; X-ray
; 2.40 A; A=221-533
PDB
3VP0; X-ray
; 2.40 A; A=221-533
PDB
3VP1; X-ray
; 2.30 A; A=221-533
PDB
3VP2; X-ray
; 2.70 A; A=221-533
PDB
3VP3; X-ray
; 2.70 A; A=221-533
PDB
3VP4; X-ray
; 2.45 A; A=221-533
PDB
4O7D; X-ray
; 2.30 A; A=221-531
PDB
5D3O; X-ray
; 2.79 A; A/B=72-597
PDB
5FI2; X-ray
; 2.50 A; A/B/C/D=72-597
PDB
5FI6; X-ray
; 2.52 A; A/B/C/D=72-597
PDB
5FI7; X-ray
; 2.50 A; A/B/C/D=72-597
PDB
5HL1; X-ray
; 2.40 A; A/B/C/D=72-597
PDB
5I94; X-ray
; 2.98 A; A/B/C/D=72-597
PDB
5JYO; X-ray
; 2.10 A; A/B/C/D/E/F/G/H=221-533
PDB
5JYP; X-ray
; 2.74 A; A=221-533
PDBsum
3CZD; -
; .
PDBsum
3UNW; -
; .
PDBsum
3UO9; -
; .
PDBsum
3VOY; -
; .
PDBsum
3VOZ; -
; .
PDBsum
3VP0; -
; .
PDBsum
3VP1; -
; .
PDBsum
3VP2; -
; .
PDBsum
3VP3; -
; .
PDBsum
3VP4; -
; .
PDBsum
4O7D; -
; .
PDBsum
5D3O; -
; .
PDBsum
5FI2; -
; .
PDBsum
5FI6; -
; .
PDBsum
5FI7; -
; .
PDBsum
5HL1; -
; .
PDBsum
5I94; -
; .
PDBsum
5JYO; -
; .
PDBsum
5JYP; -
; .
ProteinModelPortal
O94925; -
; .
SMR
O94925; -
; .
BioGrid
109006; 41
; .
DIP
DIP-50591N; -
; .
IntAct
O94925; 3
; .
MINT
MINT-4096121; -
; .
STRING
9606.ENSP00000317379; -
; .
BindingDB
O94925; -
; .
ChEMBL
CHEMBL2146302; -
; .
DrugBank
DB00142; L-Glutamic Acid
; .
DrugBank
DB00130; L-Glutamine
; .
GuidetoPHARMACOLOGY
2891; -
; .
iPTMnet
O94925; -
; .
PhosphoSitePlus
O94925; -
; .
SwissPalm
O94925; -
; .
BioMuta
GLS; -
; .
EPD
O94925; -
; .
MaxQB
O94925; -
; .
PaxDb
O94925; -
; .
PeptideAtlas
O94925; -
; .
PRIDE
O94925; -
; .
TopDownProteomics
O94925-2; -. [O94925-2]
; .
DNASU
2744; -
; .
Ensembl
ENST00000320717; ENSP00000317379
; ENSG00000115419. [O94925-1]; .
Ensembl
ENST00000338435; ENSP00000340689
; ENSG00000115419. [O94925-3]; .
GeneID
2744; -
; .
KEGG
hsa:2744; -
; .
UCSC
uc002use.4; human. [O94925-1]
; .
CTD
2744; -
; .
DisGeNET
2744; -
; .
GeneCards
GLS; -
; .
H-InvDB
HIX0161645; -
; .
HGNC
HGNC:4331; GLS
; .
HPA
HPA036223; -
; .
MIM
138280; gene
; .
neXtProt
NX_O94925; -
; .
OpenTargets
ENSG00000115419; -
; .
PharmGKB
PA28734; -
; .
eggNOG
KOG0506; Eukaryota
; .
eggNOG
COG2066; LUCA
; .
GeneTree
ENSGT00390000010463; -
; .
HOGENOM
HOG000216891; -
; .
HOVERGEN
HBG005856; -
; .
InParanoid
O94925; -
; .
KO
K01425; -
; .
OMA
FMNKMAG; -
; .
OrthoDB
EOG091G03YU; -
; .
PhylomeDB
O94925; -
; .
TreeFam
TF313359; -
; .
BRENDA
3.5.1.2; 2681
; .
Reactome
R-HSA-210500; Glutamate Neurotransmitter Release Cycle
; .
Reactome
R-HSA-5628897; TP53 Regulates Metabolic Genes
; .
Reactome
R-HSA-70614; Amino acid synthesis and interconversion (transamination)
; .
SABIO-RK
O94925; -
; .
ChiTaRS
GLS; human
; .
EvolutionaryTrace
O94925; -
; .
GenomeRNAi
2744; -
; .
PRO
PR:O94925; -
; .
Proteomes
UP000005640; Chromosome 2
; .
Bgee
ENSG00000115419; -
; .
CleanEx
HS_GLS; -
; .
ExpressionAtlas
O94925; baseline and differential
; .
Genevisible
O94925; HS
; .
GO
GO:0005829; C:cytosol
; IEA:UniProtKB-SubCell; .
GO
GO:0005759; C:mitochondrial matrix
; IBA:GO_Central; .
GO
GO:0005739; C:mitochondrion
; IDA:UniProtKB; .
GO
GO:0004359; F:glutaminase activity
; IDA:UniProtKB; .
GO
GO:0008652; P:cellular amino acid biosynthetic process
; TAS:Reactome; .
GO
GO:0007268; P:chemical synaptic transmission
; IEA:Ensembl; .
GO
GO:0006537; P:glutamate biosynthetic process
; IDA:UniProtKB; .
GO
GO:0014047; P:glutamate secretion
; TAS:Reactome; .
GO
GO:0006543; P:glutamine catabolic process
; IDA:UniProtKB; .
GO
GO:0051289; P:protein homotetramerization
; IDA:UniProtKB; .
GO
GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process
; IEA:Ensembl; .
GO
GO:0001967; P:suckling behavior
; IEA:Ensembl; .
Gene3D
1.25.40.20; -
; 1; .
Gene3D
3.40.710.10; -
; 1; .
HAMAP
MF_00313; Glutaminase
; 1; .
InterPro
IPR002110; Ankyrin_rpt
; .
InterPro
IPR020683; Ankyrin_rpt-contain_dom
; .
InterPro
IPR012338; Beta-lactam/transpept-like
; .
InterPro
IPR015868; Glutaminase
; .
PANTHER
PTHR12544; PTHR12544
; 1; .
Pfam
PF12796; Ank_2
; 1; .
Pfam
PF04960; Glutaminase
; 1; .
SMART
SM00248; ANK
; 2; .
SUPFAM
SSF48403; SSF48403
; 1; .
SUPFAM
SSF56601; SSF56601
; 1; .
TIGRFAMs
TIGR03814; Gln_ase
; 1; .
PROSITE
PS50297; ANK_REP_REGION
; 1; .
PROSITE
PS50088; ANK_REPEAT
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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